The Black Plague was not the first or last plague that Europe suffered. Many of the painted images are of later plagues. The paintings from the 1300 depict the social situation rather than images of the disease.
A Medieval Song about the Plague
"A sickly season," the merchant said,
"The town I left was filled with dead,
and everywhere these queer red flies
crawled upon the corpses' eyes,
eating them away."
"Fair make you sick," the merchant said,
"They crawled upon the wine and bread.
Pale priests with oil and books,
bulging eyes and crazy looks,
dropping like the flies."
"I had to laugh," the merchant said,
"The doctors purged, and dosed, and bled;
"And proved through solemn disputation
"The cause lay in some constellation.
"Then they began to die."
"First they sneezed," the merchant said,
"And then they turned the brightest red,
Begged for water, then fell back.
With bulging eyes and face turned black,
they waited for the flies."
"I came away," the merchant said,
"You can't do business with the dead.
"So I've come here to ply my trade.
"You'll find this to be a fine brocade..."
And then he sneezed.